Enzymatic hydrolysis of heterocyclic nitriles

N Klempier, A De Raadt, H Griengl…

Index: Klempier, Norbert; Raadt, Anna de; Griengl, Herfried; Heinisch, Gottfried Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 1 p. 93 - 95

Full Text: HTML

Citation Number: 17

Abstract

Abstract Chemoselective hydrolysis of heterocyclic nitriles can be achieved by an easy to use immobilized biocatalyst prepared from Rhodococcus sp. Pyrimidine-2-carbonitrile (2a) and 3-chloropyridazine-4-carbonitrile (4a) were converted into the corresponding amides while from 2-ethoxycarbonyl-4-pyridinecarbonitrile (1a), 6-methylpyridazine-3-carbonitrile (3a), 3-chloropyridazine-4-carbonitrile (4a), 3-ethoxycarbonyl-4, 5-dihydroisoxazole-5- ...