Pharmaceutical research

Potential beneficial metabolic interactions between tamoxifen and isoflavones via cytochrome P450-mediated pathways in female rat liver microsomes

J Chen, SC Halls, JF Alfaro, Z Zhou, M Hu

Index: Chen, Jun; Halls, Steven C.; Alfaro, Joshua F.; Zhou, Zhaohui; Hu, Ming Pharmaceutical Research, 2004 , vol. 21, # 11 p. 2095 - 2104

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Citation Number: 45

Abstract

Abstract Purpose. This study aims to evaluate a cytochrome P450-based tamoxifen- isoflavone interaction and to determine the mechanisms responsible for inhibitory effects of isoflavones (eg, genistein) on the formation of α-hydroxytamoxifen. Methods. Metabolism studies were performed in vitro using female rat liver microsomes. The effects of genistein and an isoflavone mixture on tamoxifen metabolism and the inhibition mechanism were ...