Haloacetylated enol ethers 10. Condensation of β-alkoxyvinyl trifluoromethyl ketones with thiosemicarbazide. Synthesis of new trifluoromethyl 4, 5-dihydro-1H-1- …

HG Bonacorso, AD Wastowski, N Zanatta…

Index: Bonacorso; Wastowski; Zanatta; Martins; Naue Journal of Fluorine Chemistry, 1998 , vol. 92, # 1 p. 23 - 26

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Citation Number: 69

Abstract

The synthesis of 3-aryl [alkyl]-5-hydroxy-5-trifluoromethyl-4, 5-dihydro-1H-1- pyrazolethiocarboxyamides (2a–g) from the direct cyclo-condensation reaction of β- alkoxyvinyl trifluoromethyl ketones (1a–g) with thiosemicarbazide in methanol, under mild conditions, is reported. Similarly, the 1H-1-pyrazolethiocarboxyamide derivatives (2a–g) were easily dehydrated and the thiocarboxyamide group hydrolyzed in a one-step ...

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