Synthesis of new praziquantel analogues: potential candidates for the treatment of schistosomiasis

…, M Chandrasekharam, L Pica-Mattoccia, D Cioli…

Index: Sadhu, Partha Sarathi; Kumar, Singam Naveen; Chandrasekharam, Malapaka; Pica-Mattoccia, Livia; Cioli, Donato; Rao, Vaidya Jayathirtha Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1103 - 1106

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Citation Number: 20

Abstract

An efficient synthesis of antischistosomal drug praziquantel and analogues was achieved and the synthetic route designed was to afford structurally diverse analogues for better structure–activity relationship understanding. Total of nineteen PZQ analogues with structural variations at amide, piperazine and aromatic moieties have been synthesized and fully characterized. Among all the new analogues tested for antischistosomal activity, one ...