Chemical Communications

Enantioselective Friedel–Crafts alkylation reaction of indoles with α, β-unsaturated acyl phosphonates catalyzed by chiral phosphoric acid

P Bachu, T Akiyama

Index: Bachu, Prabhakar; Akiyama, Takahiko Chemical Communications, 2010 , vol. 46, # 23 p. 4112 - 4114

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Citation Number: 38

Abstract

A variety of indoles underwent enantioselective Friedel Crafts alkylation with α, β- unsaturated acyl phosphonates in the presence of 10 mol% chiral BINOL-based phosphoric acid and subsequent treatment with methanol and DBU to give methyl 3-(indol-3-yl) propanoates in good yields and with high enantioselectivities.