Synlett

Synthesis of lipophilic N9-benzylguanine derivatives

JEB McCallum, KG Huston, JM McSweeney…

Index: McCallum, Jeremy E. B.; Huston, Kenneth G.; McSweeney, Jacqueline M.; Rucker, Brandie G. Synlett, 2010 , # 19 p. 2871 - 2874

Full Text: HTML

Citation Number: 1

Abstract

The reaction of 2-N-acetylguanine with 7 in DMF at 80 ˚C resulted in the formation of four products, namely, 2-N-acetyl-N 9 -[3,5-bis(tert-butyldimethylsilyloxy)benzyl]-guanine (11), [²5] 2-N-acetyl-N 7 -[3,5-bis(tert-butyldimethylsilyloxy)benzyl]guanine (12), [²6] and the monosilylated derivatives 2-N-acetyl-N 9 -[3-(tert-butyldimethylsilyloxy)-5-hydroxybenzyl]guanine and 2-N-acetyl-N 7 -[3-(tert-butyldimethylsilyloxy)-5-hydroxybenzyl]guanine in 20, 20, 14, and ...

Related Articles:

Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase

[Fournier, Diane; Poirier, Donald European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 4227 - 4237]

Anxiolytic activity of analogues of 4-benzylamino-2-methyl-7H-pyrrolo [2, 3-d] pyrimidines

[European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 363 - 374]

A new synthetic route to donor–acceptor porphyrins

[Tetrahedron, , vol. 58, # 12 p. 2405 - 2413]

Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase

[European Journal of Medicinal Chemistry, , vol. 46, # 9 p. 4227 - 4237]

More Articles...