Mild reductive cleavage of the 9-anthracenesulfonamido function. The 9-anthracenesulfonyl (Ans) group: a new approach to the protection of the guanidino function of …

HB Arzeno, DS Kemp

Index: Arzeno, Humberto B.; Kemp, D. S. Synthesis, 1988 , # 1 p. 32 - 36

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Citation Number: 13

Abstract

Convenient syntheses of L--arginine derivatives bearing the 9eanthracenesullonyl (Ans) protective group at the w-guanidino site are described. Simple arginine-containing peptides bearing the Ans group are shown to be stable to the normal conditions of peptide synthesis. The Ans group is removed either by acidolysis with trifiuoroacetic acid over a period of hours or by a variety of novel, mild reducing conditions including reaction with alurninuin ...