Tetrahedron

Regioselective addition of organomagnesium reagents to N-silyl activated nicotinic acid esters—a convenient method for the synthesis of 4, 4-disubstituted 1, 4- …

CA Sperger, KT Wanner

Index: Braeckow, Jan; Wanner, Klaus T. Tetrahedron, 2006 , vol. 62, # 10 p. 2395 - 2404

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Citation Number: 11

Abstract

The addition of RMgX or R2Mg to nicotinic acid esters, activated with triisopropylsilyl triflate, was investigated. The regioselectivity of this reaction, where 4-unsubstituted and 4- substituted pyridine derivatives were employed as starting materials, was examined.

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