Synthesis of uracil nucleotide analogs with a modified, acyclic ribose moiety as P2Y 2 receptor antagonists

R Sauer, A El-Tayeb, M Kaulich, CE Müller

Index: Sauer, Roland; El-Tayeb, Ali; Kaulich, Marko; Mueller, Christa E. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 14 p. 5071 - 5079

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Citation Number: 16

Abstract

A series of new uracil nucleotide analogs (monophosphates, triphosphates, and phosphonates) was synthesized, in which the ribose moiety was replaced by acyclic chains, including branched or linear alkyl or dialkylether linkers. 1-ω-Bromoalkyluracil derivatives (2) were converted to the corresponding alcohols by treatment with sodium hydroxide and subsequently phosphorylated using phosphorus oxychloride followed by hydrolysis to ...