Synthetic communications

Improved method for demethylation of nitro-catechol methyl ethers

DA Learmonth, PC Alves

Index: Learmonth, David A.; Alves, Paula C. Synthetic Communications, 2002 , vol. 32, # 4 p. 641 - 649

Full Text: HTML

Citation Number: 18

Abstract

Several nitro-catechol compounds, useful as inhibitors of COMT were obtained in excellent yield and purity via an improved procedure for demethylation of the corresponding methyl ethers using aluminium chloride and pyridine in ethyl acetate. ... Several nitro-catechol compounds, useful as inhibitors of COMT were obtained in excellent yield and purity via an improved procedure for demethylation of the corresponding methyl ethers using aluminium chloride and ...