Chemistry and physics of lipids

Trigger lipids inducing pH-dependent liposome fusion

Y Ogawa, M Kodaka, H Okuno

Index: Ogawa, Yoshikatsu; Kodaka, Masato; Okuno, Hiroaki Chemistry and Physics of Lipids, 2002 , vol. 119, # 1-2 p. 51 - 68

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Citation Number: 9

Abstract

Aspartic acid-derived artificial lipids (ADLs; s indicates the number of the methylene groups, s= 2, 4, 6, 8, 10, 12)(Scheme 1) with various carboxyl alkyl chains as head groups are designed and synthesized, which are incorporated into liposome membranes by sonication. Fluorescence resonance energy transfer (FRET) measurements indicate that ADL6, ADL8 and ADL10 have high lipid-mixing ability in the acidic solution. The other ADLs, however, ...

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