Synthesis, structure–activity relationships and preliminary antitumor evaluation of benzothiazole-2-thiol derivatives as novel apoptosis inducers

…, XH Shi, J Wang, T Zhou, YZ Xu, TT Huang…

Index: Wang, Zhao; Shi, Xuan-Hong; Wang, Jia; Zhou, Tian; Xu, You-Zhi; Huang, Ting-Ting; Li, Yan-Fang; Zhao, Ying-Lan; Yang, Li; Yang, Sheng-Yong; Yu, Luo-Ting; Wei, Yu-Quan Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1097 - 1101

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Citation Number: 46

Abstract

A series of novel benzothiazole-2-thiol derivatives were synthesized, and their anti- proliferative activities on HepG2 and MCF-7 cells were investigated. Most compounds had inhibitory effects on cell growth, and some of them were more effective than cisplatin. Compounds 6m and 6t displayed good inhibitory activities against a panel of different types of human cancer cell lines, with IC50 values in the low micromolar range. Further ...