Tetrahedron

Cyclisation at very high temperature. Thermal transformations of N-alkyl and N, N-dialkyl amides of α, β-unsaturated acids into mono-and bicyclic heterocycles under …

S Leśniak, RB Nazarski, B Pasternak

Index: Lesniak, Stanislaw; Nazarski, Ryszard B.; Pasternak, Beata Tetrahedron, 2009 , vol. 65, # 32 p. 6364 - 6369

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Citation Number: 7

Abstract

Cyclisations of N-alkyl and N, N-dialkyl cinnamic amides to the corresponding pyrrolidin-2- ones under the conditions of flash vacuum thermolysis (FVT), are described. It was found that these reactions proceed at 950–1000° C affording in various yields the mixtures of isomeric mono and bicyclic γ-lactams, which were separated chromatographically and analysed by means of NMR spectroscopy. Two alternative mechanisms for the title ...

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