The Journal of organic chemistry

Palladium-catalyzed regioselective oxidative coupling of indoles and one-pot synthesis of acetoxylated biindolyls

Z Liang, J Zhao, Y Zhang

Index: Liang, Zunjun; Zhao, Jinlong; Zhang, Yuhong Journal of Organic Chemistry, 2010 , vol. 75, # 1 p. 170 - 177

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Citation Number: 96

Abstract

Mild conditions have been developed to achieve Pd-catalyzed homocoupling of indoles with excellent regioselectivity in the presence of Cu (OAc) 2· H2O in DMSO at room temperature in high efficiency. This method provides a simple route to 2, 3′-biindolyls from the electron- rich to moderately electron-poor indoles. The reaction tolerates the bromide substituent on indoles. In addition, a one-pot approach to C3-position acetoxylated biindolyls is realized ...

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