Efficient syntheses of biologically important (S)-2-amino-8-oxodecanoic acid (Aoda) and homologues

S Kim, EY Kim, H Ko, YH Jung

Index: Kim, Sanghee; Kim, Eun-Young; Ko, Hyojin; Jung, Young Hoon Synthesis, 2003 , # 14 p. 2194 - 2198

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Citation Number: 10

Abstract

Abstract The efficient and practical asymmetric syntheses of the biologically important (S)-2- amino-8-oxodecanoic ester and its homologues have been achieved employing the Schöllkopf chiral auxiliary. Carbon-carbon bond formation between the appropriate alkyl bromide and the LDA generated anion of the Schöllkopf auxiliary, followed by hydrolysis provided the desired methyl ester of a long-chained keto amino acid in high yield with ...