Antiandrogenic activity of anthranilic acid ester derivatives as novel lead structures to inhibit prostate cancer cell proliferation

…, S Degen, R Matusch, A Baniahmad

Index: Roell, Daniela; Roesler, Thomas W.; Degen, Stephanie; Matusch, Rudolf; Baniahmad, Aria Chemical Biology and Drug Design, 2011 , vol. 77, # 6 p. 450 - 459

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Citation Number: 11

Abstract

A plant extract from the fruits of saw palmetto, which is currently used to treat the androgendependent benign prostatic hyperplasia and PCa, served as source for new structure variants. We investigated the antiandrogenic potential of an ethanolic total extract and one of its main aromatic components anthranilic acid. An androgen receptor- antagonistic (antiandrogenic) effect of the extract was evident, and although anthranilic ...