Electrochemical A-ring bromination of estrogens

I Damljanovic, M Vukicevic, RD Vukicevic

Index: Damljanovic, Ivan; Vukicevic, Mirjana; Vukicevic, Rastko D. Bulletin of the Chemical Society of Japan, 2007 , vol. 80, # 2 p. 407 - 409

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Citation Number: 4

Abstract

A-ring bromination of estrogens has been achieved by constant current electrolysis of the solutions of these substrates and Et 4 NBr in appropriate solvents. Thus, electrolysis consuming 2 F mol− 1 charge gave mixtures of 2-and 4-estrogens (1: 1.1–2.5; up to 97%), whereas 4 F mol− 1 charge experiments yielded 2, 4-dibromoestrogens as the sole products.