Bleomycin: synthesis and structural verification of the tripeptide S and tetrapeptide S moieties

MD Levin, K Subrahamanian, H Katz…

Index: Levin; Subrahamanian; Katz; et al. Journal of the American Chemical Society, 1980 , vol. 102, # 4 p. 1452 - 1453

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Citation Number: 10

Abstract

The antitumor antibiotic bleomycin has attracted considerable interest because of its activity against certain human malignancies and the prospect that new bleomycin analogues may find even greater utility in the clinic.'S2 A structure was first proposed for bleomycin in 19723 and has recently been revised to that shown (1, bleomycin A2). 4 Additionally, the