Preparation of 5-Hydroxy-2-iodopyridine: A Refutation of Earlier Reports

PW Sheldrake, LC Powling…

Index: Sheldrake, Peter W.; Powling, Laurence C.; Slaich, Pritpal K. Journal of Organic Chemistry, 1997 , vol. 62, # 9 p. 3008 - 3009

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Citation Number: 8

Abstract

Recent work in this department needed a sample of 5-hydroxy-2-iodopyridine (1a). The literature reveals modern work apparently describing the preparation of 1a, mp 188-189 C, by iodination of 3-hydroxypyridine using sodium iodide and sodium hypochlorite in a methanol/water system. 1 Also, material prepared in this way is reported as the starting material for the preparations of L-β-(5-hydroxy-2-pyridyl) alanine2 and a derivative3 of this ...