A new synthetic route to 4, 6??diarylpyridazinones and some of their derivatives

P Coudert, J Couquelet…

Index: Coudert, P.; Couquelet, J.; Tronche, P. Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 799 - 802

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Citation Number: 30

Abstract

Abstract A novel approach to the titled ring system starting from conveniently available chalcones 1 is proposed. It involves a catalysed exchange of hydrogen cyanide between acetone cyanohydrin and 1. The resulting γ-ketonitriles 2 give the expected 4, 6- diarylpyridazinones 4 and 5 via hydrolysis and cyclisation by hydrazine. The action of phosphorus oxychloride on 5 followed by that of amines provides aminopyridazines 7.

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