Molecules

Synthesis of chalcones with anticancer activities

S Syam, SI Abdelwahab, MA Al-Mamary, S Mohan

Index: Syam, Suvitha; Abdelwahab, Siddig Ibrahim; Al-Mamary, Mohammed Ali; Mohan, Syam Molecules, 2012 , vol. 17, # 6 p. 6179 - 6195

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Citation Number: 88

Abstract

Abstract Several chalcones were synthesized and their in vitro cytotoxicity against various human cell lines, including human breast adenocarcinoma cell line MCF-7, human lung adenocarcinoma cell line A549, human prostate cancer cell line PC3, human adenocarcinoma cell line HT-29 (colorectal cancer) and human normal liver cell line WRL- 68 was evaluated. Most of the compounds being active cytotoxic agents, four of them with ...