Strain-Promoted Oxidation-Controlled Cyclooctyne–1, 2-Quinone Cycloaddition (SPOCQ) for Fast and Activatable Protein Conjugation

A Borrmann, O Fatunsin, J Dommerholt…

Index: An, Peng; Yu, Zhipeng; Lin, Qing Organic Letters, 2013 , vol. 15, # 21 p. 5496 - 5499

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Citation Number: 15

Abstract

... Early studies during the 1970s and 1980s described the reaction of plain cyclooctyne with various 1,2-quinones in organic solvents.(29-31) It has also been shown that 1,2 ... We synthesized a bifunctional linker 12 (Figure 3c) containing both an azide and a catechol moiety. ...

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