Potential antidepressants displayed combined α2-adrenoceptor antagonist and monoamine uptake inhibitor properties

…, I Berque-Bestel, T Persigand, JM Lacoste…

Index: Cordi; Berque-Bestel; Persigand; Lacoste; Newman-Tancredi; Audinot; Millan Journal of Medicinal Chemistry, 2001 , vol. 44, # 5 p. 787 - 805

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Citation Number: 45

Abstract

Classical antidepressants are thought to act by raising monoamine (serotonin and noradrenaline) levels in the brain. This action is generally accomplished either by inhibition of monoamine metabolism (MAO inhibitors) or by blockade of monoamine uptake (tricyclic antidepressants and selective serotonin or noradrenaline reuptake inhibitors). However, all such agents suffer from a time lag (3-6 weeks) before robust clinical efficacy can be ...

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