Synthesis

One-pot synthesis of 1, 3-dinitroalkanes under heterogeneous catalysis

R Ballini, G Bosica, D Fiorini, A Palmieri

Index: Ballini, Roberto; Bosica, Giovanna; Fiorini, Dennis; Palmieri, Alessandro Synthesis, 2004 , # 12 p. 1938 - 1940

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Citation Number: 12

Abstract

Abstract Reaction of aldehydes with an excess of nitromethane in the presence of basic alumina as solid catalyst allows the one pot preparation of 1, 3-dinitroalkanes. The synthesis proceeds through the nitroaldol reaction of nitromethane, which acts both as nucleophile and as solvent, to the aldehydes with the formation of β-nitroalkanols as intermediates that convert to nitroalkenes. Further nucleophilic behavior of the nitromethane produces the in ...