Pharmacological evaluation of some new 2-substituted pyridine derivatives.

…, J Parthiban, N Anbalagan, V Gunasekaran…

Index: Narendar, Parasuraman; Parthiban, Jeyaraman; Anbalagan, Navaneetharaman; Gunasekaran, Vedachalam; Thomas Leonard, Joseph Biological and Pharmaceutical Bulletin, 2003 , vol. 26, # 2 p. 182 - 187

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Citation Number: 11

Abstract

In the present study, a series of 2-substituted-pyridines were synthesized and characterized by IR, 1 H-NMR and Elemental Analysis. The compounds were assayed against seizures induced by maximal electro shock (MES) and pentylenetetrazole (scMet). Neurologic deficit was evaluated by the rotarod test. The decrease in the elevated motor activity by introceptive chemical stimuli (amphetamine antagonistic activity) was studied at the dose level of 25 ...