On the regioselectivity of the reaction of cyanothioacetamide with 2-acetylcyclo-hexanone, 2-acetylcyclopentanone, and 2-acetyl-1-(morpholin-4-yl)-1-cycloalkenes

VV Dotsenko, SG Krivokolysko, VV Polovinko…

Index: Dotsenko; Krivokolysko; Polovinko; Litvinov Chemistry of Heterocyclic Compounds, 2012 , vol. 48, # 2 p. 309 - 319

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Citation Number: 7

Abstract

It has been established that the interaction of cyanothioacetamide with 2- acetylcyclohexanone, 2-acetylcyclopentanone, or their enamines (2-acetyl-1-(morpholin-4- yl)-1-cycloalkenes) contrary to the literature data have a non-regiospecific character and leads to the formation of mixtures of 3-cyano-4-methyl-5, 6-tri (tetra) methylenepyridine-2 (1 H)-thiones and 3-cyano-6-methyl-4, 5-tri (tetra) methylene-pyridine-2 (1 H)-thiones with a ...