Synthesis of reactive fluoroaliphatic diamines

AE Mera, JR Griffith, K Baum

Index: Mera, Ann E.; Griffith, James R.; Baum, Kurt Journal of Fluorine Chemistry, 1990 , vol. 49, # 3 p. 313 - 320

Full Text: HTML

Citation Number: 3

Abstract

Abstract The synthesis of “reactive”(ie aminoacylated) fluoroaliphatic diamines [H 2 N (CH 2) 3 C ( O) NHCH 2 CH 2 (CF 2) n CH 2 CH 2 NHC ( O)(CH 2) 3 NH 2; n= 4, 8] has been accomplished through the use of peptide blocking group and coupling techniques. Also, the synthetic route to these diamines and their dihydrobromide salts has been improved over that of a recently published procedure.