… agonists with different degrees of intrinsic activity within a series of 2-(4-aminophenyl)-N, N-dipropylethylamine derivatives: synthetic chemistry and structure-activity …

…, V Hillegaart, A Malmberg, A Wijkstroem…

Index: Florvall; Hillegaart; Malmberg; Wijkstroem; Ahlenius European Journal of Medicinal Chemistry, 1996 , vol. 31, # 2 p. 133 - 142

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Citation Number: 5

Abstract

A series of 2-(4-aminophenyl)-N, N-dipropylethylamine derivatives were synthesized and tested for in vivo intrinsic activity at brain dopamine receptors in the rat. Differences in the sensitivity of dopamine receptors pre-and post-synaptically in the reserpine-treated rat were used to estimate the intrinsic activity of the various compounds as dopamine receptor agonists. Thus, the ability of the compounds to antagonize reserpine-induced increase in ...