Mn (III)-based radical addition reactions of 2-nitroindole with activated CH compounds

DA Androsov, TLS Kishbaugh, GW Gribble

Index: Androsov, Dmitry A.; Kishbaugh, Tara L.S.; Gribble, Gordon W. Tetrahedron Letters, 2008 , vol. 49, # 47 p. 6621 - 6623

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Citation Number: 7

Abstract

2-Nitroindole undergoes addition reactions with the radicals generated from active CH compounds upon treatment with Mn (OAc) 3· 2H2O to afford the corresponding 3-substituted- 2-nitroindoles in 27–66% yields. Products of the methylene addition reactions undergo a subsequent in situ Nef reaction to afford 2-oxoindolin-3-ylidenes.