An expedient route to a versatile intermediate for the stereoselective synthesis of all-trans-retinoic Acid and beta-carotene

JH Babler, SA Schlidt

Index: Babler; Schlidt Tetrahedron Letters, 1992 , vol. 33, # 50 p. 7697 - 7700

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Citation Number: 15

Abstract

Abstract Base-catalyzed isomerization of vinyl phosphonate 5 afforded the corresponding allylic phosphonate (6) as the sole product. Horner-Emmons olefination of ethyl trans-3- methyl-4-oxo-2-butenoate with the ylide derived from 6 concludes a facile synthesis of the all-