Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogs. Synthesis, structure, and interactions with IMP …
G Gebeyehu, VE Marquez, A Van Cott…
Index: Gebeyehu; Marquez; van Cott; Cooney; Kelley; Jayaram; Ahluwalia; Dion; Wilson; Johns Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 99 - 105
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Citation Number: 84
Abstract
A series of dinucleotides, analogous to nicotinamide adenine dinucleotide but containing the five-membered base nucleosides tiazofurin (la), selenazofurin (Ib), ribavirin (2), and AICAR (3) in place of nicotinamide ribonucleoside, were prepared in greater than 50% yield by reacting the corresponding nucleotide imidazolidates (6a-d) with adenosine 5'- monophosphate (AMP). The symmetric dinucleotides of tiazofurin (TTD, 8e) and ...
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