An Efficient Synthesis of Carbamates by Tin-Catalyzed Transcarbamoylation Reactions of Primary and Secondary Alcohols

Y Ichikawa, Y Morishita, S Kusaba, N Sakiyama…

Index: Ichikawa, Yoshiyasu; Morishita, Yukinori; Kusaba, Shuhei; Sakiyama, Naoto; Matsuda, Yasunori; Nakano, Keiji; Kotsuki, Hiyoshizo Synlett, 2010 , # 12 p. 1815 - 1818

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Abstract

Abstract A new approach to the synthesis of carbamates based on a tin-catalyzed transcarbamoylation process has been developed. Reactions of primary and secondary alcohols with phenyl carbamate in toluene at 90 C proceed smoothly in the presence of tin- catalyst to generate the corresponding carbamates in good yields. This mild method exhibits a broad functional-group tolerance.