Bioorganic & medicinal chemistry

Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs)

QH Chen, PNP Rao, EE Knaus

Index: Schmid; Schultes; Wichtl Monatshefte fuer Chemie, 1954 , vol. 85, p. 80,84

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Citation Number: 34

Abstract

... Bioorganic & Medicinal Chemistry. Volume 14, Issue 23, 1 December 2006, Pages 7898–7909. ... 15, 0, —, >100, 1.2, >85, >10, >10. ... The C-3 p-C(Me) N–OH substituted phenyl ring is oriented toward a hydrophobic pocket comprised of Phe381, Leu384, Tyr385, Trp387, and Met522 ...

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