Cyclopropyl containing fatty acids as mechanistic probes for cytochromes P450

…, PR Ortiz de Montellano, JJ De Voss

Index: Cryle, Max J.; Ortiz De Montellano, Paul R.; De Voss, James J. Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2455 - 2469

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Citation Number: 34

Abstract

The mechanism of aliphatic hydroxylation by cytochromes P450 has been the subject of intense debate with several proposed mechanistic alternatives. Various cyclopropyl containing compounds (radical clocks), which can produce both unrearranged and ring opened products upon oxidation, have been key tools in these investigations. In this study, we introduce several cyclopropyl containing fatty acids 1a-4a with which to probe the ...