Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective …

PN Praveen Rao, M Amini, H Li…

Index: Banks, Ronald Eric; Flowers, William Thain; Khaffaf, Suad Najmaldin Journal of Fluorine Chemistry, 1991 , vol. 53, # 1 p. 127 - 142

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Citation Number: 74

Abstract

... Journal of Medicinal ... Chemistry. ... In this C-6 alkyl subgroup (14a−e) of compounds, a p-fluoro substituent on the C-4 phenyl ring decreased both COX-2 selectivity and inhibitory potency but increased COX-1 inhibitory potency (Table 1). In the C-6 alkoxy (OMe, OEt, OPr-i, OBu-t ...