Antitumor activity of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, is highly dependent on its primary structure and steric configuration

…, X Ling, S Cao, X Liu, S Wan, T Jiang, F Li

Index: Zhao, Jiuyang; Ling, Xiang; Cao, Shousong; Liu, Xiaojun; Wan, Shengbiao; Jiang, Tao; Li, Fengzhi Molecular Pharmaceutics, 2014 , vol. 11, # 2 p. 457 - 467

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Citation Number: 11

Abstract

We recently reported the identification and characterization of a novel small chemical molecule designated FL118. FL118 selectively inhibits multiple cancer survival and proliferation-associated antiapoptotic proteins (survivin, Mcl-1, XIAP, cIAP2) and eliminates small and large human tumor xenografts in animal models (Ling et al., PLoS One 2012, 7, e45571). Here, we report a follow-up study on the structure–activity relationship (SAR) of ...