Aldehydes from dihydro-1, 3-oxazines. II. Synthesis of. alpha.,. beta.-unsaturated aldehydes and their C-1 deuterated derivatives

AI Meyers, A Nabeya, HW Adickes…

Index: Meyers,A.I. et al. Journal of the American Chemical Society, 1969 , vol. 91, p. 764 - 765

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Citation Number: 34

Abstract

Journal of the American Cliemicul Society 1 91: 3 1 Junuarj 29, cursors to a variety of aliphatic aldehydes. We now wish to describe the reaction of these oxazine anions with a host of carbonyl compounds, giving rise to good yields of the adducts, 2, which are useful precursors to conjugated aldehydes. Addition of aldehydes or ketones to the THF solution of the lithio salt of 1 (a or b) at-78'followed by hydrolytic work-up produces near quantitative ...

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