One-pot synthesis of polysubstituted imidazoles in a Brønsted acidic deep eutectic solvent

L Wang, X Zhong, M Zhou, W Zhou…

Index: Wang, Liang; Zhong, Xia; Zhou, Min; Zhou, Wei-You; Chen, Qun; He, Ming-Yang Journal of Chemical Research, 2013 , vol. 37, # 4 p. 236 - 238

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Citation Number: 3

Abstract

A Brønsted acidic deep eutectic solvent based on choline chloride and p-toluenesulfonic acid was prepared and was found to be effective for the one-pot synthesis of 2, 4, 5- trisubstituted and 1, 2, 4, 5-tetrasubstituted imidazoles with high yields. In addition, the deep eutectic solvent is non-toxic, cost-effective and recyclable.