The [(Cp) M (CO) 3](M= Re, 99mTc) Building Block for Imaging Agents and Bioinorganic Probes: Perspectives and Limitations

D Can, HW Peindy N'Dongo, B Spingler…

Index: Can, Daniel; Peindy N'Dongo, Harmel W.; Spingler, Bernhard; Schmutz, Paul; Alberto, Roger; Raposinho, Paula; Santos, Isabel Chemistry and Biodiversity, 2012 , vol. 9, # 9 p. 1849 - 1866,18

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Citation Number: 13

Abstract

Abstract Starting from asymmetric Thiele's acid derivatives, two different imaging probes [99m Tc (CO) 3 (CpR)](R= potential targeting vector) are generated simultaneously in one- pot and from one substrate. This extends the previously introduced labeling strategy of metal- mediated retro-Diels [BOND] Alder reaction with HCp-R dimers. We demonstrate that chemically active functionalities such as hydroxamic acids are not following this labeling ...