Molluscicidal activity of synthetic lapachol amino and hydrogenated derivatives

TMS Silva, CA Camara, TP Barbosa, AZ Soares…

Index: Silva, Tania M.S.; Camara, Celso A.; Barbosa, Ticiano P.; Soares, Andre Z.; Da Cunha, Luciana C.; Pinto, Angelo C.; Vargas, Maria D. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 1 p. 193 - 196

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Citation Number: 100

Abstract

A series of new amino derivatives and a new partially hydrogenated derivative of the natural naphthoquinone lapachol were assayed for molluscicidal activity against Biomphalaria glabrata. These derivatives showed low to medium LC50 values, and a 3.1 μg/mL value for the most potent derivative of the series. The toxicity is in agreement with the decrease of polar character of the tested compounds.