β??Disubstituted Allylic Chlorides: Substrates for the Cu??Catalyzed Asymmetric SN2′ Reaction

…, K Tissot??Croset, A Alexakis

Index: Falciola, Caroline A.; Tissot-Croset, Karine; Alexakis, Alexandre Angewandte Chemie - International Edition, 2006 , vol. 45, # 36 p. 5995 - 5998

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Citation Number: 70

Abstract

Metal-promoted asymmetric catalysis has proven to be an efficient method in carbon–carbon bond-forming reactions to obtain optically enriched compounds. Allylic substitution has attracted much attention and great effort has been put into controlling the chemo-, regio-, and enantioselective outcome of the reaction.[1] Extensive accounts report a wide variety of metals that use soft nucleophiles for the reaction (Pd, Ir, Mo, Rh, Ru).[2] In contrast, copper ...