Arkivoc

Improved synthesis of 2-arylhydrazono-3-hydroxy-1-propanones and their utility in efficient synthesis of pyridazine derivatives

NA Al-Awadi, MR Ibrahim, AM Al-Etaibi, MH Elnagdia

Index: Al-Awadi, Nouria A.; Ibrahim, Maher R.; Al-Etaibi, Alya M.; Elnagdi, Mohamed H. Arkivoc, 2011 , vol. 2011, # 2 p. 310 - 321

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Abstract

Abstract Reaction of 2-arylhydrazono-1-phenylethanones 2a-c with formaldehyde either in presence of montmorillonite K10 or by simply stirring in methanol and TEA leads to selective synthesis of 2-arylhydrazono-3-hydroxy-1-phenylpropan-1-one derivatives 3a-c in high yield. Heating 1a with N-phenylmaleimide in DPE/DABCO using microwave irradiation for 5 minutes at 200 oC results in a 73% yield of pyrrolo [3, 4-c] pyridazine 8. Compounds 2a-c ...