(1-Benzylindole-3-yl) alkanoic Acids; Novel Nonsteroidal Inhibitors of Steroid 5. ALPHA.-Reductase (I).

…, H Hirai, P Golden, S OKADA, Y SAWADA…

Index: Sawada, Kozo; Hirai, Hideo; Golden, Patrick; Okada, Satoshi; Sawada, Yuki; Hashimoto, Masashi; Tanaka, Hirokazu Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 11 p. 1683 - 1687

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Citation Number: 11

Abstract

A novel series of indole-3-alkanoic acids with varied N-benzyl substituents were synthesized as nonsteroidal inhibitors of steroid 5α-reductase. The structure-activity relationship in this series were studied and the optimum carboxylic acid side chain was butyric acid. Furthermore, compounds with a diaryl substituent at the 1-position of the indole ring displayed strong inhibitory activities in vitro. Amongst these derivatives, 4-[1-(6, 6-dimethyl ...