Structure-reactivity relations for thiol-disulfide interchange

J Houk, GM Whitesides

Index: Houk,J.; Whitesides,G.M. Journal of the American Chemical Society, 1987 , vol. 109, p. 6825

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Citation Number: 160

Abstract

Abstract: Equilibrium constants were determined for thiol-disulfide interchange between 36 di-and trithiols and the disulfides derived from either 2-mercaptoethanol or dithiothreitol. Reactions were conducted in methanol-d,/aqueous buffer (pH 7) or methanold, at 25 “C, using NMR spectroscopy to follow the reactions. These data were used to rank the dithiols in terms of reduction potential and to infer the structure of the disulfides formed from them on ...