Synthesis of N-arylated sultams: palladium-and copper-catalyzed cross coupling of aryl halides with 1, 4-butane and 1, 3-propanesultams

D Steinhuebel, M Palucki, D Askin, U Dolling

Index: Steinhuebel, Dietrich; Palucki, Michael; Askin, David; Dolling, Ulf Tetrahedron Letters, 2004 , vol. 45, # 16 p. 3305 - 3307

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Citation Number: 35

Abstract

Palladium-catalyzed cross coupling of 1, 4-butanesultam and 1, 3-propanesultam with a variety of aryl halides was found to provide the desired products in 62–93% isolated yield using Xantphos as ligand. The Pd-catalyzed reaction was found to be superior to the analogous Cu-catalyzed reaction based on product yields, reaction rates, and substrate scope.