Synthesis of Cephalosporin??Type Antibiotics by Coupling of Their β??Lactam Nucleus and Racemic Amino Acid Side Chains Using a Clathration??Induced Asymmetric …

GJ Kemperman, J Zhu, AJH Klunder…

Index: Kemperman, Gerardus J.; Zhu, Jie; Klunder, Antonius J. H.; Zwanenburg, Binne European Journal of Organic Chemistry, 2001 , # 10 p. 1817 - 1820

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Citation Number: 3

Abstract

Abstract The cephalosporin-type antibiotics Cephalexin, Cephradine and Cefadroxil have been prepared by coupling of their β-lactam nucleus and racemic amino acid side chain precursors. The initially obtained mixture of cephalosporin epimers is subjected to a clathration-induced asymmetric transformation which results in the epimerization of the epi- cephalosporin into the cephalosporin with the correct diastereomeric configuration.