Chemical modification of glycyrrhetinic acid in relation to the biological activities.

…, K HIRABAYASHI, M YAMAMOTO, N NAGATA

Index: Shibata; Takahashi; Yano; Harada; Saito; Tamura; Kumagai; Hirabayashi; Yamamoto; Nagata Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 5 p. 1910 - 1918

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Citation Number: 64

Abstract

18β-Olean-12-ene-3β, 30-diol (deoxoglycyrrhetol)(4a) was prepared with a view to eliminating pseudoaldosteronism, a side-effect of glycyrrhetinic acid (1b), which is the sapogenin of Licorice saponin, glycyrrhizin (1a), while maintaining or enhancing the therapeutic activities. On reduction of the 11-keto and 30-carboxyl groups of 1b with NaAlH 2- (OCH 2 CH 2 OCH 3) 2, olean-12-ene-3β, 11β, 30-triol (9) and olean-12-ene-3β, 11α, 30- ...