Synthesis and dehydrogenation of spinaceamine and spinacine 4-hetaryl derivatives

…, MG Abramyants, TI Zavyazkina, DI Matveeva…

Index: Smolyar; Abramyants; Zavyazkina; Matveeva; Borodkin, Ya. S.; Voloskii Russian Journal of Organic Chemistry, 2009 , vol. 45, # 8 p. 1219 - 1223

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Citation Number: 4

Abstract

Abstract The reaction of histamine and histidine with various hetarylaldehydes under the conditions of the base-catalyzed Pictet-Spengler process affords 4-hetaryl-substituted derivatives of spinaceamine and spinacine. The dehydrogenation of the 4-hetaryl- substituted spinaceamine derivatives using elemental sulfur in DMF at 120–130° C led to the formation of 4-hetaryl derivatives of imidazo [4, 5-c]-pyridine. Under similar conditions ...