Discovery of N-{(1 S, 2 S)-2-(3-Cyanophenyl)-3-[4-(2-[18F] fluoroethoxy) phenyl]-1-methylpropyl}-2-methyl-2-[(5-methylpyridin-2-yl) oxy] propanamide, a Cannabinoid- …

…, S Sanabria, X Tong, J Wang, DA Levorse…

Index: Liu, Ping; Lin, Linus S.; Hamill, Terence G.; Jewell, James P.; Lanza Jr., Thomas J.; Gibson, Raymond E.; Krause, Stephen M.; Ryan, Christine; Eng, Waisi; Sanabria, Sandra; Tong, Xinchun; Wang, Junying; Levorse, Dorothy A.; Owens, Karen A.; Fong, Tung M.; Shen, Chun-Pyn; Lao, Julie; Kumar, Sanjeev; Yin, Wenji; Payack, Joseph F.; Springfield, Shawn A.; Hargreaves, Richard; Burns, H. Donald; Goulet, Mark T.; Hagmann, William K. Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3427 - 3430

Full Text: HTML

Citation Number: 33

Abstract

The discovery of a structurally distinct cannabinoid-1 receptor (CB1R) positron emission tomography tracer is described. Starting from an acyclic amide CB1R inverse agonist (1) as the lead compound, an efficient route to introduce 18F to the molecule was developed. ...