Tetrahedron letters

Total synthesis of an antitumor antibiotic,(±)-duocarmycin SA

H Muratake, I Abe, M Natsume

Index: Muratake, Hideaki; Abe, Itsuko; Natsume, Mitsutaka Tetrahedron Letters, 1994 , vol. 35, # 16 p. 2573 - 2576

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Citation Number: 39

Abstract

Abstract A 12-step total synthesis of (±)-duocarmycin SA (1) was achieved from a readily available pyrrole 3 by way of 7, 10/11, 14 and 18, using a SnCl 2-mediated reaction of a singlet oxygen adduct 6 with 5, as well as the Heck and Mitsunobu reactions on 9 and 16 as key steps.